# X-Ray Crystallography and Macromolecular Characterization

> **NIH NIH P30** · THOMAS JEFFERSON UNIVERSITY · 2022 · $104,288

## Abstract

XSR Summary 
The mission of the Sidney Kimmel Cancer Center X-Ray Crystallography and Macromolecular Characterization 
Shared Resource (XSR) is to facilitate the design, acquisition, and interpretation of quantitative data relevant to 
the structure and function of cancer-related macromolecules; decipher the impact of mutations on protein 
folding and stability; and promote the understanding of macromolecular interactions at atomic detail. The XSR 
provides a single portal for SKCC members who require crystallization, X-ray data collection, structure 
determination, and functional dissection of macromolecular interactions. Founded in 2009, the XSR is the only 
facility of its kind in Philadelphia and is uniquely positioned to fill the needs of cancer biologists in 
macromolecular structure analysis and characterization by providing a unique array of specialized instruments 
that build upon expertise in biophysics, structural, and chemical biology. When former XSR Director Dr. John 
Pascal relocated to the University of Montreal in 2015, Gino Cingolani, PhD, took over as Director of the XSR. 
Co-Director Michael Root, PhD, continues to oversee the instrumentation dedicated to macromolecular 
characterization. Anshul Bhardwaj, PhD, the XSR facility manager, oversees the day-to-day operations of the 
XSR and supports the research of SKCC members through facility services and scientific collaboration. 
Current XSR goals are as follows: 1) Serve the needs of SKCC research programs in crystallization, X-ray data 
collection, structure determination, and biophysical characterization of macromolecules; 2) Assist with the 
design, acquisition, and interpretation of quantitative data relevant to the structure and function of cancer- 
related macromolecules; 3) Facilitate studies on how mutations impact folding, stability, and interactions of 
proteins important in oncogenesis.

## Key facts

- **NIH application ID:** 10447610
- **Project number:** 5P30CA056036-23
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **Principal Investigator:** MICHAEL JEFFREY ROOT
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $104,288
- **Award type:** 5
- **Project period:** 1995-06-22 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10447610

## Citation

> US National Institutes of Health, RePORTER application 10447610, X-Ray Crystallography and Macromolecular Characterization (5P30CA056036-23). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10447610. Licensed CC0.

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