# Core 5: Integrated Support Services

> **NIH NIH UC7** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 · $2,076,371

## Abstract

Core 5: Integrated Research Support Services
Abstract
The Integrated Research Support Services (ISS) Core serves to organize shared services that are provided to
the research community within the NEIDL. These services support BSL-4/ABSL-4 studies to ensure that each
investigator does not have to recreate infrastructure and expertise in their laboratories in order to carry out their
funded research programs. The core will develop schedules and manage costs so that reasonable and
responsible user fees are charged to investigators using these services to offset overall costs, as appropriate.
The services offered evolve over time such that new services can be offered as the needs of the research
community changes. Currently, core is broadly separated into the Animal Research Support Services, and the
BSL-4 Laboratory Services. Animal Research Services includes trained veterinary professionals and veterinary
technicians who collaborate with faculty to carry out studies in various animal models. The team is trained on a
number of procedures to increase safety when working with animals, especially those that require the use of
sharps. This unit also works with investigators to ensure the humane use of animals and to comply with
institutional animal care and use committee requirements. Within the BSL-4 Laboratory Services, a number of
units exist to support the BSL-4 and ABSL-4 studies. These include Veterinary Pathology (anatomic and
laboratory) Service which oversees the necropsy services, storage and maintenance of the samples in
compliance with the CDC select agent program, and is responsible for establishing and validating the
inactivation protocols required to move tissues to the BSL-2. The Veterinary Pathologist is responsible for
clinical chemistry. Virology Services is responsible for receiving, validating, and inventorying viruses that are
utilized in BSL-4 research. This includes generating master and working stocks as well as maintaining an
accurate inventory of agents. This core also develops advanced virologic tools as needed. The Viral Genomic
Tracking and Single Cell omics Resource is responsible for ensuring the fidelity of viral stocks from VS given to
investigators for their research, and for initiating single cell sequencing and single virus omics technologies in
the BSL-4. The Imaging Services Unit provides several platforms to study living tissue specimens infected with
BSL-4 pathogens, including Light Sheet microscopy. Many of the BSL-4 investigators rely on services from the
NEIDL Comparative Pathology Laboratory (NCPL). Immunology Services provides training, guidance and
maintenance of advanced immunology instrumentation inside the BSL-4 footprint, including flow cytometry.
High-throughput screening has been operationalized to include automated visual screening of virus infected
cells treated with small molecule inhibitors, and can be adapted to any virus or cell target. Linking the Clinic to
NEIDL Programs includes a clinician w...

## Key facts

- **NIH application ID:** 10447708
- **Project number:** 5UC7AI095321-09
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** RONALD B CORLEY
- **Activity code:** UC7 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,076,371
- **Award type:** 5
- **Project period:** 2014-06-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10447708

## Citation

> US National Institutes of Health, RePORTER application 10447708, Core 5: Integrated Support Services (5UC7AI095321-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10447708. Licensed CC0.

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