# Core C:  Customized Physiology and Imaging Core

> **NIH NIH P20** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2022 · $271,686

## Abstract

PROJECT SUMMARY
The new Customized Imaging and Physiology Core of the proposed Vermont Center for Cardiovascular and
Brain Health COBRE will be based upon transformation of a Neuroscience Imaging Core from a previous
COBRE (completed in 2016). It will meet the new needs of cutting-edge imaging investigation that will be
pursued by Project Directors (PDs) in the newly proposed COBRE. We will employ acquisition of needed
technology and renovation to accommodate its operation. The Customized Physiology and Imaging Core will
be designed to provide state-of-the-art imaging capabilities for live samples, including intravital, tissue and cell
preparations, as well as fixed samples. The new Cardiovascular and Brain Health COBRE will involve
extensive training in in vivo imaging and electrophysiology, and exploitation of genetically-encoded indicators
and optically-actuated probes by Project Directors. This Core will have high level pre- and post-experiment
technical and analytical support from Todd Clason, Dr. Grant Hennig and Dr. Tom Heppner. The new era of
high-resolution microscopy requires the flexibility to image in awake animals that may be undergoing specific
tasks, and to image in 3 dimensions over a wide range of time periods from milliseconds to weeks. To
accomplish this, this Core will advise and train investigators in the use of different types of state-of-art high
spatial and temporal resolution microscopy, electrophysiological techniques, and 3D printing for instrument
design and fabrication to respond to changing research needs, as well as in use and development of image
and electrophysiological analysis software. The goal of this Core is to equip the investigators with
imaging/electrophysiological, fabrication and analysis skills so that they are capable of adapting approaches to
solve complex problems. It is anticipated that this Core will greatly enhance the competitiveness of COBRE
Project Directors as well as campus-wide investigators in cardiovascular and brain health research. This Core
is unique in that PDs and other investigators, with support from highly accomplished Core personnel, will
acquire the skills to perform the experiments, modify imaging modalities, to fabricate project-specific
equipment, and to perform high level image analysis.

## Key facts

- **NIH application ID:** 10447828
- **Project number:** 5P20GM135007-03
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Grant Hennig
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $271,686
- **Award type:** 5
- **Project period:** 2020-08-06 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10447828

## Citation

> US National Institutes of Health, RePORTER application 10447828, Core C:  Customized Physiology and Imaging Core (5P20GM135007-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10447828. Licensed CC0.

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