Project Abstract The University of Illinois (UI) Veterinary Diagnostic Laboratory (VDL) is a full service, AAVLD accredited, all species, reference laboratory. UI VDL is a member of the VET-LIRN. Since last April, UI VDL has tested over one thousand of samples for SARS-CoV-2 and more than one hundred of samples of large cats in four different zoos were tested positive. These positive and negative samples are important for SARS-CoV-2 clinical and research related activities. New freezer and Nanodrop will significantly increase our storage and testing capacity for routine case investigation and surveillance coordinated by Vet-LIRN.