# Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

> **NIH NIH K24** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $188,296

## Abstract

Project Summary
This is an application for K24 award renewal for Dr. Lea T. Grinberg, a neuropathologist at the University of
California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the
UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient-
oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating,
managing, and analyzing well-characterized postmortem collections of brains belonging to people at-risk or
already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international
investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience,
expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant
writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the
UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies, research
portfolio, and her collaborations with multidisciplinary researchers in the areas of dementia domestically and
worldwide. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve
as training vehicles for mentees and expand her research. These studies, using clinical, genetic, and
neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH-
funded cohort studies of persons with Alzheimer's disease (AD). She will examine the factors underlying selective
neuronal vulnerability in AD. In summary, this K24 will enhance Dr. Ginberg's active research program with
extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases,
especially in the field of neuropathology, and to develop a program of excellence for training medical students,
trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps
caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for
neuropathologists.

## Key facts

- **NIH application ID:** 10448265
- **Project number:** 5K24AG053435-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Lea Tenenholz Grinberg
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $188,296
- **Award type:** 5
- **Project period:** 2016-08-15 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10448265

## Citation

> US National Institutes of Health, RePORTER application 10448265, Neuropathological changes underlying clinical heterogeneity in Alzheimer disease (5K24AG053435-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10448265. Licensed CC0.

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