The UCSF CTSI's “K Scholars Program” integrates KL2 awardees and other K mechanism/career development awardees in one of most successful such training programs in the nation. Scholars matriculate with the methodologic, analytic, leadership, and team science skills required to conduct transformative clinical and translational research, with a strong track record of attaining research independence. The Program does not duplicate existing programs at UCSF and is a vital resource for junior faculty from the Schools of Medicine, Nursing, Dentistry, and Pharmacy. The Program supports Scholars across the entire translational spectrum, with notable impact in clinical, behavioral, and health services research across the lifespan and for underserved populations. This renewal focuses on providing emerging skills that will be fundamental to successful careers in team science-based clinical and translational research, proposing state-of-the-art training in clinical informatics, data science (DS), and implementation science (ImS). The K Scholars Program will continue to leverage UCSF's unique strengths and partnerships to extend the impact of the Program by achieving the following Specific Aims: Aim I.1. To continue to select and train a superb group of UCSF junior faculty KL2 Scholars from diverse scientific disciplines, and to support them for up to 3 years as they progress toward research independence. The Program will support a total of 9 KL2 positions (3 new, 3- 2nd year, 3- 3rd year) in each of the grant years, providing up to 3 years of KL2 funding per Scholar. The Program will continue all of the key training and mentoring elements of its highly successful K Scholars Program, and enrich further opportunities to promote research independence and to integrate special populations into clinical and translational research; Aim I.2. To provide state-of-the-art informatics and DS training, mentorship, and practical experience to advance clinical medicine and improve public health. An increasingly important goal of much health care research is to extract knowledge and insights from large and/or complex datasets. This Aim will increase and facilitate K Scholars' access to new informatics and DS didactic opportunities, along with research consultation and collaboration opportunities with expert Faculty; Aim I.3. To provide ImS training, mentorship, and practical experience to accelerate the dissemination of clinical and translational research into clinical practice and public health. This Aim will train K Scholars to successfully translate scientific evidence into improved practice, policy, and population health, with a variety of ImS didactic and experiential offerings, along with research consultation and collaboration opportunities with expert Faculty; Aim I.4. To share and disseminate the successful elements of the K Scholars Program for local, regional, and national collaboration. The Program will create new opportunities for UCSF CTSI Scholars and Faculty ...