# Core Facility for Aged Rodents

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $137,600

## Abstract

Abstract
The principal goal of the Core Facility for Aged Rodents (CFAR) is to develop new mouse models that can
be used to evaluate the physiological and cellular factors that control the rate of aging and tie aging to late-life
diseases. New mouse models are often suggested by other scientists, at UM or at other institutions, and these
are evaluated as potential collaborations. CFAR resources are used for initial characterizations, often
including studies of lifespan, age-sensitive indices of health, and pathology, with a view towards producing
sufficient data to allow the new mouse models to be used in competitive applications for extramural support. In
keeping with the overall theme of the UM OAIC, many of the mouse systems developed depend on alterations
of metabolic and/or inflammatory pathways, whether by genetic changes, dietary interventions, or, more
recently, drugs. The specific mutants, diets, or drugs chosen each year depend on scientific discoveries and
interactions in each preceding year. Specific Aims: Aim 1 will support six externally funded projects (EPs) in
year 1, including work on serotonin receptor mutants, drug effects on gene expression patterns, effects of anti-
aging drugs on cancer cells, work on cap-independent translation of specific mRNAs, studies of adipose tissue
inflammation, and an analysis of over-expression of an enzyme that protect mitochondria from oxidative
damage. Aim 2 uses CFAR resources to maintain breeding colonies of special interest to mouse aging
research, including mutants with tissue-specific alterations in Growth Hormone receptor, the IGF1 binding
protein protease PAPPA, the mitochondrial redox protecting enzyme thioredoxin reductase 2, and two proteins
that promote cap-independent translation of mRNA subsets. Aim 3 focuses on training, consultation, and
professional education, so that CFAR can provide sophisticated perspectives on mouse aging models to PES
and REC applications, and to UM students, fellows and faculty, and contribute to development of national
standards for optimal use of rodents in biogerontology. Aim 4 involves selection of one or two new innovative
mouse models for development in each year of the award. CFAR has, since its inception in 1989, provided
both local and national leadership in the development of new mouse models for research on the control of
aging and its links to late-life diseases, and hopes to maintain this role in the next award period.

## Key facts

- **NIH application ID:** 10448480
- **Project number:** 5P30AG024824-18
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** RICHARD A MILLER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $137,600
- **Award type:** 5
- **Project period:** 2004-09-30 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10448480

## Citation

> US National Institutes of Health, RePORTER application 10448480, Core Facility for Aged Rodents (5P30AG024824-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10448480. Licensed CC0.

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