# Mechanism and function of transplacental IgD

> **NIH NIH R01** · WAYNE STATE UNIVERSITY · 2022 · $385,000

## Abstract

Project Summary
Allergies are becoming a major cause of neonatal morbidity, with food allergies showing increased incidences
and significantly affecting young infants, some of which can be serious or fatal, and are associated with long-
term morbidity, imposing heavy social and economic burdens. For neonatal food allergy, no effective treatment
is currently available except avoiding or replacing the offending food, which is often impossible due to the
ubiquitous nature of some food components. Hence, there is a critical need to identify effective means of
strengthening the immune function of neonates to improve their immediate and long-term health. Human
respiratory mucosa and blood harbor secreted immunoglobulin D (IgD). We found that IgD is important in
respiratory immune defense by inhibiting mucosal adhesion of pathogens and activating antimicrobial and
immune-amplifying functions of basophils. IgD activation of basophils also suppresses IgE-induced allergic
functions, and increased food allergen-specific IgD production correlates with protection against food allergy
after oral immunotherapy in children. Maternal tetanus, diphtheria, and acellular pertussis (TDaP) vaccine and
food exposure in pregnancy induces the production of vaccine- and food-specific IgD that is transferred across
the placenta to the fetus in humans and mice. The objectives here are to understand the mechanisms of the
placental transfer of IgD and to determine if maternal IgD promotes neonatal immune protection against food
allergy. We hypothesize that maternal IgD specific to vaccines or food acts as a specific and prophylactic fetal
immune education cue to protect neonates against food allergy. Of note, the basophil-activating and anti-
allergic functions are unique to IgD and not possessed by IgG. Employing biochemical and imaging techniques
in cell culture, human placenta specimens and mouse models, studies in Aim 1 will mechanistically elucidate
the placental transfer of maternal IgD. Aim 2 will determine the function of maternal food-specific IgD in the
protection against IgE-mediated neonatal food allergy by integrating neonatal mouse models of IgE-mediated
food-induced anaphylaxis with human cord or peripheral blood specimens of newborn babies with or without
food allergy in the first year of life. Our study is expected to reveal the unique functions of maternal IgD, an
ancient yet still mysterious antibody, in neonatal immune function that maternal IgG does not have, but also
have a profound impact on improving neonatal health by directing the design of IgD-targeting maternal
vaccines or adoptive immunotherapies.

## Key facts

- **NIH application ID:** 10448491
- **Project number:** 5R01AI163045-02
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **Principal Investigator:** Kang Chen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $385,000
- **Award type:** 5
- **Project period:** 2021-07-09 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10448491

## Citation

> US National Institutes of Health, RePORTER application 10448491, Mechanism and function of transplacental IgD (5R01AI163045-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10448491. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*