# Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplement

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2021 · $135,411

## Abstract

PROJECT SUMMARY/ABSTRACT
This application is for the NIBIB C3i Accell program. The objective of our parent R01 application
(R01EB030102, Project Period: 08/01/2020–04/30/2024) is to perform small animal and large animal studies to
obtain compelling preclinical evidence needed to support future clinical translation of focused ultrasound-enabled
liquid biopsy (sonobiopsy). Through learnings from NIBIB’s C3i programs, we identified that one key risk
toward commercialization of our technique is the need to optimize the design of the sonobiopsy device
for clinical use and validated its feasibility and safety in biomarker release. The objective of our proposed
research for the C3i Accell program is to address this key technical risk. Successful completion of this work will
obtain data that will support our start-up company’s NIH SBIR/STTR grant application to further commercial
development efforts.

## Key facts

- **NIH application ID:** 10448708
- **Project number:** 3R01EB030102-02S1
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Hong Chen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $135,411
- **Award type:** 3
- **Project period:** 2021-08-19 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10448708

## Citation

> US National Institutes of Health, RePORTER application 10448708, Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplement (3R01EB030102-02S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10448708. Licensed CC0.

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