# Core 1: Biospecimen and Biomarker Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $232,779

## Abstract

The Biospecimen and Biomarker Core provides the leadership and expertise in biospecimen sciences and
molecular analyses needed in this P01 to investigate the metabolic signatures of molecular subtypes of glioma
to improve patient management. High-quality, well-annotated biospecimens and rigorous and standardized
analysis of tumor tissue are essential for testing the hypotheses associated with the scientific Projects. The
Core will acquire, annotate, distribute, track, and analyze brain tumor patient biospecimens from the operating
room. This will include the acquisition and analysis of image-guided and multiple spatially mapped samples
from patients with newly-diagnosed and recurrent glioma. In addition, the Core will provide histopathologic and
molecular analysis of human glioma xenografts. All aspects of this Core are performed in accordance with the
guiding principles set forth in the 2016 National Cancer Institute Best Practice for Biorepository Guidelines. The
specific aims of the Biospecimen and Biomarker Core are as follows:
1. To acquire and preserve high-quality biospecimens, including image-guided and spatially mapped tissue
 samples, from the operating room to meet the tissue accrual requirements for the scientific projects.
2. To perform the clinically relevant molecular analyses required by the Projects.
3. To provide the neuropathologic expertise for interpretation of the processed tissue sections and extraction
 of appropriate quantitative and semi-quantitative parameters.
4. To maintain a tissue inventory and database of associated molecular parameters that is linked to the Brain
 Tumor Center Database, integrating imaging, clinical, molecular, and pathology data.
5. To provide consistent oversight of the Core activities that will ensure the stringent compliance with
 regulations governing informed consent and patient confidentiality, as well as management of the
 biospecimens and the information derived from the biospecimens.

## Key facts

- **NIH application ID:** 10449387
- **Project number:** 5P01CA118816-14
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Joanna Phillips
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $232,779
- **Award type:** 5
- **Project period:** 2007-07-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10449387

## Citation

> US National Institutes of Health, RePORTER application 10449387, Core 1: Biospecimen and Biomarker Core (5P01CA118816-14). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10449387. Licensed CC0.

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