# Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics

> **NIH NIH U01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $117,893

## Abstract

Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics
Acute pancreatitis (AP) leads to oxidative and inflammatory injury, ensuing parenchymal damage, exocrine
and/or endocrine insufficiencies including the development of diabetes. While AP increases the risk of the
development of diabetes, the type of diabetes, either type 1 diabetes (T1D, autoimmune) as compared to other
forms of diabetes, is not clear. Considering diabetes is a major health disparity in our country, understanding
AP-driven diabetes is needed in racially diverse populations. Additionally, the risk factors or the mechanisms
lead to AP driven diabetes is also unclear. Importantly, the gut microbiota is a novel factor linked to the genesis
of both T1D and type 2 diabetes (T2D), yet its role in AP driven diabetes is not known. Moreover, in our diverse
patient population, the compositional profiles of gut microbiota are not well defined. Our proposal leverages our
extensive, multiple institutional, cohort of patients which is predominantly African American (AA) and Hispanic
and our broad, multidiscplinary team with a range of expertise in clinical pancreatology and diabetes, gut
microbiome, diet and health disparities research. In sum, the goal of our proposal is three-fold: 1) to define in
our diverse patient population that is predominantly AA and Hispanic, the relationship between AP to T1D, and
other forms of diabetes, and the factors associated with development of diabetes, and to mechanistically define
2) how diet, specifically enriched in animal protein and fat (DH-APF), through its interaction with the gut
microbiota, impacts AP-driven diabetes, and 3) how fiber from the diet, through the generation of short chain
fatty acids (SCFAs), a recently recognized factor identified in the genesis of T1D and T2D, mediates AP-driven
T1D.

## Key facts

- **NIH application ID:** 10449719
- **Project number:** 3U01DK127378-02S1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Brian Thomas Layden
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $117,893
- **Award type:** 3
- **Project period:** 2020-09-17 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10449719

## Citation

> US National Institutes of Health, RePORTER application 10449719, Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics (3U01DK127378-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10449719. Licensed CC0.

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