# BEHAVIORAL PHENOTYPING CORE

> **NIH NIH P50** · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2022 · $156,616

## Abstract

PROJECT SUMMARY/ABSTRACT – BEHAVIORAL PHENOTYPING CORE 
 The Behavioral Phenotyping Core (BPC) supports development, implementation, and dissemination of a 
broad spectrum of scientific inquiries focused on understanding mechanisms affecting brain development, 
behavior, and cognition among individuals with intellectual and developmental disabilities (IDD). Unique Core 
attributes include: (1) access to data about a wide range of genetic and neurodevelopmental disorders, via a 
registry and research database of over 27,000 individuals with deep neurocognitive/behavioral phenotyping; 
(2) significant expertise in assessment and intervention with very low functioning individuals, including those 
with sensory, motor, and/or communication impairments, and individuals with the most severe and challenging 
behaviors; (3) ability to implement remote assessments through wearable and video-based assessment 
technology; (4) a catalog of over 500 validated quantitative neuropsychological and behavioral assessment 
instruments, ready to implement in clinical trials via highly- trained examiners; (5) a state-of-the-art motion 
analysis unit equipped with movement imaging, robotics, force analysis, sensation and proprioception 
measurement capabilities; and (6) clinical and research neurophysiology resources, including a full range 
measurements available through EEG and polysomnography. These unique Core features allow for 
researchers to investigate the full range of biomarkers (neuroimaging, physiologic, “-omic”) in IDD, and to link 
these directly to deep behavioral phenotyping in humans. 
 Specific aims are accomplished primarily through the integration of Core faculty expertise with resources, 
facilities, equipment, and direct services from four complementary units within the Core, including behavior 
analysis, motion analysis, developmental neuropsychology and clinical neurophysiology. With these rich and 
diverse resources, development and validation of a wide range of outcome measures for clinical trial readiness 
in IDD, is a fundamental component of the Core, along with dissemination or resources and scientific 
discoveries.

## Key facts

- **NIH application ID:** 10450076
- **Project number:** 5P50HD103538-03
- **Recipient organization:** HUGO W. MOSER RES INST KENNEDY KRIEGER
- **Principal Investigator:** Ernest Mark Mahone
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $156,616
- **Award type:** 5
- **Project period:** 2020-08-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450076

## Citation

> US National Institutes of Health, RePORTER application 10450076, BEHAVIORAL PHENOTYPING CORE (5P50HD103538-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10450076. Licensed CC0.

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