# O-glycoproteins in the progression of liver disease

> **NIH NIH R01** · GEORGETOWN UNIVERSITY · 2022 · $504,952

## Abstract

Abstract
We propose to apply targeted mass spectrometric methods to the analysis of specific O-glycoforms of proteins
in the progression of liver disease to hepatocellular carcinoma (HCC). We have identified novel sialylated O-
glycoform of liver secreted proteins significantly increased at progressive stages of liver disease. We propose
to determine structure of the glycoforms and to evaluate extent of their presence on liver secreted
glycoproteins. We will study association of the O-glycoforms with progressing stages of liver pathology by their
direct quantification at specific sites of protein attachment in serum of patients. The O-glycoforms will be
analyzed in combination with other markers identified in previous studies. We combine current concepts of
disease mechanisms and advanced technologies to design improved serologic assays expected to
complement biopsy and other non-invasive procedures in the assessment of liver disease. Non-invasive
monitoring of liver disease progression to HCC is expected to influence optimal selection of therapeutic
approaches and improve disease outcomes.

## Key facts

- **NIH application ID:** 10450085
- **Project number:** 5R01CA238455-04
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** RADOSLAV GOLDMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $504,952
- **Award type:** 5
- **Project period:** 2019-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450085

## Citation

> US National Institutes of Health, RePORTER application 10450085, O-glycoproteins in the progression of liver disease (5R01CA238455-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10450085. Licensed CC0.

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