# The National Drug Abuse Clinical Trials Network: New England Consortium Node

> **NIH NIH UG1** · YALE UNIVERSITY · 2021 · $1,700,000

## Abstract

ABSTRACT
This study will (1) recruit, train and provide resources to approximately 30 Emergency Department (ED) sites
throughout the U.S. using implementation facilitation strategies to provide ED-initiated BUP for patients
presenting with opioid use disorder (OUD) not receiving medications for opioid use disorder (MOUD). Once
implementation is adequately achieved, the sites will (2) conduct a randomized controlled trial (RCT) to
compare the effectiveness of sublingual buprenorphine (SL-BUP) versus extended-release buprenorphine
(XR-BUP) on ED patients’ engagement in formal addiction treatment 7-days after their ED visit. In addition, in
an ancillary component of the study, we will (3) assess the use of XR-BUP in ED patients with Clinical Opioid
Withdrawal Scale (COS) scores < 8 in a case series to potentially expand the eligibility of patients in the larger
RCT to those presenting with little to no opioid withdrawal symptoms. Finally, we will (4) develop and validate
ED electronic health record (HER) opioid-related phenotypes, both of which will inform the main RCT.

## Key facts

- **NIH application ID:** 10450554
- **Project number:** 3UG1DA015831-20S5
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Gail D'Onofrio
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,700,000
- **Award type:** 3
- **Project period:** 2021-03-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450554

## Citation

> US National Institutes of Health, RePORTER application 10450554, The National Drug Abuse Clinical Trials Network: New England Consortium Node (3UG1DA015831-20S5). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10450554. Licensed CC0.

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