# Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal Approach

> **NIH NIH K01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $105,318

## Abstract

Abstract
The PI for this K01 mentored career development award is a junior investigator focused on the intersection
between epidemiology, sleep medicine, and women’s health. She examines the impact of sleep on health, using
contemporary analytical approaches. Her career goal is to advance understanding of pathways through which
inadequate sleep impairs cardiometabolic health in women. The proposed K01 mentored career development
award includes a 5-year plan for training, education, and research aims that will provide the skills and experience
the PI needs to become a highly successful and independent investigator.
Insufficient sleep is a major public health burden, linked to cardiometabolic morbidity and mortality. More women
experience poor sleep than men. These sex differences are likely endocrine-based. Indeed, sleep varies along
the menstrual cycle, but whether these sleep variations affect cardiometabolic health remains unknown. This
study will harness advanced epidemiologic methods to generate insight and hypothesis on the pathways that
link sleep and cardiometabolic diseases in premenopausal women.
The candidate will examine associations between patterns of sleep and clinically-relevant markers of
cardiometabolic diseases. To accomplish these aims, the candidate will utilize existing data from the BioCycle
study of young and racially diverse women. With a unique micro-longitudinal design, the BioCycle study followed
women serially along two consecutive menstrual cycles. Collected information includes demographic data,
medical history, anthropometric measures and serial assessments of blood, saliva, urine, and daily sleep diary
entries.
This mentored research scientist career award will focus on three learning objectives: 1) didactic education in
sleep physiology and neurobiology; 2) training in biomarker assessment and analysis; and 3) didactic education
and training in advanced quantitative methods and their application in sleep research.
The PI will be supported by an accomplished, specifically-tailored and multidisciplinary mentorship team. She
will also benefit from superb research infrastructure at Michigan Medicine, its Division of Sleep Medicine and the
School of Public Health, which has launched many productive and impactful careers in sleep research.

## Key facts

- **NIH application ID:** 10450676
- **Project number:** 5K01HL144914-04
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Galit Levi Dunietz
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $105,318
- **Award type:** 5
- **Project period:** 2019-07-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450676

## Citation

> US National Institutes of Health, RePORTER application 10450676, Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal Approach (5K01HL144914-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10450676. Licensed CC0.

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