# Infant Bronchiolitis and Viral Core (IBVC)

> **NIH NIH P01** · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $284,400

## Abstract

PROJECT SUMMARY/ABSTRACT
Respiratory syncytial virus (RSV) causes a spectrum of disease in children ranging from upper respiratory
infections to severe lower respiratory tract disease, such as bronchiolitis and pneumonia. Although the
determinants of disease progression from the upper to the lower respiratory tract, severity of bronchiolitis,
recurrences, and long-term morbidity, such as recurrent wheezing or asthma, are not fully understood, both
host- and virus-specific factors appear to contribute to the pathogenesis and/or the outcome of this infection.
The long-term goal of our P01 is to understand the role the mucosa plays in virus- and allergen-induced airway
inflammation and remodeling. We will advance our aims and the field by providing new mechanisms by which
innate viral and allergen stimuli produce epigenetic remodeling, oxidative injury and reprogramming of the
innate mucosal interferon (IFN) response. The purpose of the Infant Bronchiolitis and Viral Core (IBVC) is to
acquire high-quality, clinically annotated mucosal samples from a cohort of young children infected with
respiratory syncytial virus (RSV), and to provide a centralized scientific resource that supports the need for
optimized, homogeneous (highly reproducible) RSV preparations, immunoassay performance, and use of
state-of-the art experimental mouse models of infection, which are required in research project (RP) RP1-RP3
of our P01. Efficient management and distribution of samples and data will ensure the success of the projects.
Furthermore, the IBVC will provide services, technical and intellectual assistance to the P01 Center
investigators in a functional, cost-efficient, and multi-user environment that will enhance the productivity of both
individual and collaborative research programs. In addition to state-of-the-art equipment and methods, the key
personnel of the IBVC provide scientific and technical expertise that greatly benefits the Center investigators in
terms of experimental design, execution and interpretation, as well as, by providing a focus for collaborative
interactions.

## Key facts

- **NIH application ID:** 10450720
- **Project number:** 5P01AI062885-15
- **Recipient organization:** UNIVERSITY OF TEXAS MED BR GALVESTON
- **Principal Investigator:** Roberto P Garofalo
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $284,400
- **Award type:** 5
- **Project period:** 2004-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450720

## Citation

> US National Institutes of Health, RePORTER application 10450720, Infant Bronchiolitis and Viral Core (IBVC) (5P01AI062885-15). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10450720. Licensed CC0.

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