# Rehabilitation at home using mobile health in older adults after hospitalization for ischemic heart disease (RESILIENT)

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $628,708

## Abstract

Project Summary
Participation in ambulatory cardiac rehabilitation (CR) by patients with ischemic heart disease (IHD) remains
low. By recent estimates, fewer than two thirds of eligible patients are referred, and fewer than half of those
referred participate. Even among those referred, multiple barriers to participation include limited facilities,
competing time demands, high out-of-pocket costs, and prolonged wait time. Barriers to CR are particularly
high in older adults (age ≥70), due to factors such as physical impairments or transportation barriers, although
these patients may simultaneously have the greatest potential to benefit. Mobile health-enabled CR (mHealth-
CR) for IHD – which involves delivery of CR via portable electronic devices – has the potential to increase
engagement by reducing participation barriers, but it remains largely untested outside of small studies in
relatively healthy young persons. It is therefore unclear what proportion of older adults with IHD and barriers to
traditional CR are able to engage with mHealth-CR, and whether mHealth-CR leads to better outcomes than
usual care. Therefore, we propose RESILIENT: Rehabilitation at home using mobile health in older adults
after hospitalization for ischemic heart disease. This is a prospective, multicenter, non-blinded randomized
clinical trial (with blinded assessment of primary endpoint) to evaluate engagement and outcomes with
mHealth-CR among older adults with IHD, identified at the time of acute myocardial infarction (AMI),
percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG). The trial will be conducted
at two academic medical centers: NYU School of Medicine and Yale School of Medicine, which collectively
serve a diverse patient population and have a track record of successfully recruiting older adults in clinical
research studies. We will randomize 400 older adults with IHD to receive mHealth-CR (n=300) or usual care
(n=100) for 3 months. Our intervention combines mHealth-CR software, delivered via a tablet device, with
baseline counseling and weekly phone calls by an exercise therapist over 3 months. Intervention and usual
care groups will also receive a standard referral to ambulatory CR in accordance with guidelines, as well as
dynamic assessment of activities of daily living (ADLs). The primary efficacy endpoint is change in functional
capacity, assessed by 6 minute walk distance. Secondary efficacy endpoints are goal attainment, health
status, ADLs, hospital readmission, and death. The engagement endpoint is defined by weekly completion of
mHealth-CR tasks. We hypothesize that mHealth-CR will improve a range of outcomes, and that distinct
patterns of engagement will be discerned. The PI for this project (Dr. Dodson) is an Early Stage Investigator
with a focus on cardiovascular outcomes research among older adults; additional investigators have a wide
range of expertise in geriatrics, biostatistics, behavioral science, cardiac rehabi...

## Key facts

- **NIH application ID:** 10450751
- **Project number:** 5R01AG062520-04
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** John A Dodson
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $628,708
- **Award type:** 5
- **Project period:** 2019-07-15 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10450751

## Citation

> US National Institutes of Health, RePORTER application 10450751, Rehabilitation at home using mobile health in older adults after hospitalization for ischemic heart disease (RESILIENT) (5R01AG062520-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10450751. Licensed CC0.

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