# Control and Impacts of Disease of Zebrafish in Research Facilities

> **NIH NIH R24** · OREGON STATE UNIVERSITY · 2021 · $117,789

## Abstract

Project Summary/Abstract - Bridge
The use of zebrafish (Danio rerio) as part of an integrative approach to improving human health is now second
to mice in vertebrate models, with over 1,000 NIH grants using the model. Certain pathogens are very
common in zebrafish facilities. The three most common diseases/infections of zebrafish in research
laboratories are microsporidiosis, caused by Pseudoloma neurophilia, mycobacteriosis (caused by multiple
species of Mycobacterium), and parasitic enteritis (caused by the nematode Pseudocapillaria tomentosa), and
now we add Mycoplasma penetrans, the picornavirus ZPV to this list. Moreover, a transmissible intestinal
cancer is also very common, and may be caused by Mycoplasma penetrans. Our proposed research
investigate the role of Mycoplasma and other agents as causes of the intestinal tumors. We will also study
pathologic effects of ZPV. We continue our work with Mycobacterium chelonae, focusing on maternal
transmission and the effects of diet. We are not asking for support to study continue research on Pseudoloma
and Pseudocapillaria as we believe we have accomplished the appropriate aims put forth in our previous
grants funded by NIH ORIP. Proposed here is Bridge Funding to maintain our unique zebrafish vivarium
so that we can soon initiate the above proposed research.

## Key facts

- **NIH application ID:** 10451091
- **Project number:** 3R24OD010998-18S1
- **Recipient organization:** OREGON STATE UNIVERSITY
- **Principal Investigator:** Michael Lawrence Kent
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $117,789
- **Award type:** 3
- **Project period:** 2003-07-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10451091

## Citation

> US National Institutes of Health, RePORTER application 10451091, Control and Impacts of Disease of Zebrafish in Research Facilities (3R24OD010998-18S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10451091. Licensed CC0.

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