# Homeostatic Plasticity in Mouse Model of Jordan's Syndrome

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $201,875

## Abstract

ABSTRACT
The identification of gene mutations that cause autism and syndromes associated with severe intellectual
disability has greatly advanced both research and new therapeutic development. Yet, the mechanisms that link
gene loss of function to impaired brain function remain poorly understood in almost every instance. There is a
pressing need to elucidate how individual gene mutations lead to deficits in brain function, with the potential to
identify common grounds for therapeutic intervention that will benefit the largest patient population. Recently,
homeostatic plasticity was demonstrated to have a potent ability to counteract neurological disease onset and
progression. This is referred to as Homeostatic Neuroprotection. Based on preliminary data, we propose that
the mechanisms of homeostatic neuroprotection also apply to the onset and progression of impaired
hippocampal function, based on work examining a new mouse model of severe intellectual disability. This work
has the potential to open a new approach toward therapeutic development in psychiatric disease.

## Key facts

- **NIH application ID:** 10451713
- **Project number:** 5R21HD106516-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** GRAEME W DAVIS
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $201,875
- **Award type:** 5
- **Project period:** 2021-07-15 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10451713

## Citation

> US National Institutes of Health, RePORTER application 10451713, Homeostatic Plasticity in Mouse Model of Jordan's Syndrome (5R21HD106516-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10451713. Licensed CC0.

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