# Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

> **NIH NIH K99** · CHILDREN'S HOSP OF PHILADELPHIA · 2022 · $799

## Abstract

PROJECT SUMMARY/ABSTRACT
Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical
function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed
K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory
mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed
application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve
the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00
application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC)
Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an
independent career as a nurse scientist with a robust program of research in pediatric critical care and
symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop
PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a
multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims
include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge;
and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge.
The candidate will develop a model through advanced statistical methods to identify children who are a-risk for
physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a
prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of
inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after
discharge will provide an opportunity for early intervention to optimize their physical function after critical
illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of
scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory
biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to
meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational
conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team,
tailored research plan and findings within this K99/R00 application will prepare her well for transition to
independence as a nurse scientist in pediatric critical care and symptom science.

## Key facts

- **NIH application ID:** 10451762
- **Project number:** 5K99GM145411-02
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** MALLORY A PERRY-EADDY
- **Activity code:** K99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $799
- **Award type:** 5
- **Project period:** 2021-08-01 → 2022-08-03

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10451762

## Citation

> US National Institutes of Health, RePORTER application 10451762, Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit (5K99GM145411-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10451762. Licensed CC0.

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