Project Summary/Abstract Transgender women, particularly Black and Latina transgender women living with HIV, are particularly vulnerable to the socioeconomic and psychosocial impacts of the COVID-19 pandemic. However, data are lacking on how the intersection of HIV, COVID-19, and structural racism affect the physical health and psychosocial outcomes among transgender women. Understanding these relationships and identifying factors that may modify them are important steps towards advancing health equity. This study combines and supplements data from existing NIH-funded prospective studies with transgender women (with and without HIV) to assess longitudinal relationships between HIV and COVID-19 disease experiences and to examine associations between structural racism, HIV, and pandemic-related health inequities among transgender women. This innovative study will analyze data from 450 transgender women to assess health outcomes along lines of race/ethnicity, HIV status, and technology access. This innovative research will provide novel information that can be used to guide public health efforts to reduce health disparities.