# CSHL 2022 Protein Homeostasis in Health and Disease Conference

> **NIH NIH R13** · COLD SPRING HARBOR LABORATORY · 2022 · $31,945

## Abstract

Cold Spring Harbor Laboratory Conference on
 Protein Homeostasis in Health and Disease
 April 26 - 30, 2022
ABSTRACT
This proposal is a request for financial support for a meeting on PROTEIN HOMEOSTASIS IN
HEALTH AND DISEASE to be held at Cold Spring Harbor Laboratory from April 26 - 30, 2022.
This meeting is the premier international forum for presentation of new results in this area, and
is attended by representatives from virtually every major laboratory in the field. The explosion of
new information on how the folded state of proteins is acquired and maintained in vivo and the
relevance of this process to healthy aging and risk for diseases of neurodegeneration, cancer,
and metabolism guarantees an excitement and urgency of this meeting. Because of the recent
developments on stress signaling in aging and disease, we will open the meeting with this new
session followed the next day with a session on protein aggregation in aging and
neurodegenerative diseases and then closing the meeting with a session on correcting
proteostasis in aging and disease. Additional sessions will address the relationship between
protein synthesis, folding, translocation and degradation by discussing the molecular
mechanisms of chaperone function, degradative mechanisms and on spatial quality control and
organellar proteostasis. The meeting will also introduce another new session on stress
granules and phase transitions that has brought many new concepts on stress physiology,
regulatory biology and novel forms of macromolecular interaction. These fundamental questions
are at the heart of biology of proteostasis that will be complemented by the sessions on aging
and proteostasis failure in diseases of protein misfolding including Alzheimer's disease, ALS,
Parkinson's disease and Huntington's disease. The themes of aging, proteostasis failure, and
diseases of protein misfolding are well integrated throughout the meeting, and emerging
principles on protein client interactions and alternate protein conformations will be
predominantly displayed. The diverse protein quality control strategies used by compartments
of the cell to ensure the integrity of the secretory and organellar pathways during times of
protein folding stress will be represented by emerging topics on spatial quality control within a
cell. The field of heat shock proteins and molecular chaperones has grown exponentially and
draws interest not only from traditional scientific disciplines in the basic sciences but also from
diverse areas of biomedical research including neurodegenerative disease, infectious diseases,
cancer, heart disease and aging. The meeting will have eight lecture sessions, two poster
sessions, two rapid-fire presentation sessions, and a panel discussion on scientific publishing.
The sessions include: 1) Integrative Stress Signaling in Biology, Aging and Disease; 2) Protein
Aggregation in Aging and Neurodegenerative Diseases; 3) Molecular Mechanisms of
Chaperones; 4) Mechanisms of Autoph...

## Key facts

- **NIH application ID:** 10452207
- **Project number:** 1R13AG077645-01
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** DAVID J. STEWART
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $31,945
- **Award type:** 1
- **Project period:** 2022-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10452207

## Citation

> US National Institutes of Health, RePORTER application 10452207, CSHL 2022 Protein Homeostasis in Health and Disease Conference (1R13AG077645-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10452207. Licensed CC0.

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