# Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs

> **NIH NIH R21** · OREGON STATE UNIVERSITY · 2022 · $205,084

## Abstract

PROJECT ABSTRACT
Saliva is the ideal biofluid for therapeutic drug monitoring applications in general, and specifically for
continuous monitoring because it is amenable to measurement noninvasively within the oral cavity. The
development of an intraoral device for the continuous real-time monitoring of anti-epileptic drugs in saliva could
enable the promise of precision medicine and advancing optimal dosing for each individual. In this project, we
will demonstrate feasibility of our proposed intraoral sensor platform by coupling capillarity-based microfluidics
and electrochemical detection to ultra-low-power readout electronics, and to use a machine-learning-based
approach for offline processing of sensor data, to create an intraoral sensor for the real-time quantification of
therapeutic drug levels in saliva in the presence of variation of salivary pH, temperature, and other common
confounders. The intraoral sensor will consist of a reusable, comfortable electronics module that will fit
securely into the patient’s mouth, and that interfaces with a disposable microfluidic chip containing
voltammetry-based detection. The intraoral sensor electronics module will communicate wirelessly with a
mobile device that will process the data and display and relay drug levels semi-continuously and in real time.

## Key facts

- **NIH application ID:** 10452435
- **Project number:** 1R21DE031101-01A1
- **Recipient organization:** OREGON STATE UNIVERSITY
- **Principal Investigator:** Elain Fu
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $205,084
- **Award type:** 1
- **Project period:** 2022-04-14 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10452435

## Citation

> US National Institutes of Health, RePORTER application 10452435, Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs (1R21DE031101-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10452435. Licensed CC0.

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