# Molecular Pathways to Pathogenesis in Toxicology

> **NIH NIH T32** · NORTH CAROLINA STATE UNIVERSITY RALEIGH · 2022 · $1

## Abstract

PROJECT SUMMARY/ABSTRACT
The North Carolina State University “Molecular Pathways to Pathogenesis in Toxicology” NIEHS T32 training
grant is a long-standing, impactful and multidisciplinary initiative that has supported 130 pre-doctoral trainees
and 18 post-doctoral researchers over the past 41 years. Graduates of this program conduct basic and applied
research, teach at universities and colleges, evaluate product safety, and assist public agencies and private
industries in resolving important public health and environmental problems. Our mission is to provide the next
generation of toxicologists/environmental health science (EHS) researchers with the technical, operational and
professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of
audiences, and work as part of multidisciplinary teams to understand how human health is impacted by
environmental factors. In this competitive renewal, we will continue with the current Molecular Pathways to
Pathogenesis in Toxicology training theme and our overarching systems biology framework. This approach aims
to integrate all levels of biological organization from biomolecules to human populations to elucidate the
fundamental mechanisms through which environmental stressors influence human health outcomes. We have
added 10 new research-active faculty for a total of 28 mentors, enhanced our mentor training requirements,
reorganized key research areas, and updated core curricula. We have enhanced our core professional
development series in scientific rigor, reasoning, experimental design and methods, and data analysis and
interpretation through formal training in science communication, training in grant writing, coding in “R”, and
methods for enhancing reproducibility. Participating mentors of this NIEHS T32 training grant are supported by
research grants from NIEHS, other NIH Institutes, other federal agencies including DOD, EPA, NSF, state
agencies and private foundations. Environmental health science research at NC State has never been stronger
as evidenced by the renewal of our NIEHS EHS Core Center (P30) and the recent award of a Superfund
Research Program (SRP) (P42). These centers serve to facilitate collaborations among participating
mentors/trainees and provide access to cutting-edge institutional infrastructure and financial support to advance
EHS research at NC State. Both centers serve as an extraordinary resource for trainees through access to core
facilities, sponsored symposia, seminars, workshops and professional development opportunities. The NIEHS
T32 training program is the foundation of NC State's highly ranked graduate program in toxicology; our well-
qualified mentors, strong pool of applicants, and rigorous and comprehensive EHS training opportunities will
ensure the continued success of this initiative. We request continued support for six trainees.

## Key facts

- **NIH application ID:** 10452637
- **Project number:** 5T32ES007046-42
- **Recipient organization:** NORTH CAROLINA STATE UNIVERSITY RALEIGH
- **Principal Investigator:** Seth William Kullman
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1
- **Award type:** 5
- **Project period:** 1977-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10452637

## Citation

> US National Institutes of Health, RePORTER application 10452637, Molecular Pathways to Pathogenesis in Toxicology (5T32ES007046-42). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10452637. Licensed CC0.

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