# Multi-racial genetic analysis of hidradenitis suppurativa

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $749,217

## Abstract

Project summary
Hidradenitis suppurativa (HS) is an underrecognized common, immune-mediated skin disease
characterized by inflammatory nodules, abscesses, and sinus tracts in the groin, buttocks, and axillae
leading to devasting physical and emotional morbidity. HS significantly affects European Americans and
minorities such as African-Americans, Asians, and Latinos. Treatments for HS are poor, with only a
single FDA-approved therapy available. The paucity of treatments is driven by a profound lack of
understanding of HS pathogenesis, particularly with respect to the genetic pathways involved. In this
application, we utilize a variety of innovative approaches to address this significant gap. First, we perform
a genome-wide association study (GWAS) in European, African American, and Asian HS cases and
healthy controls. Second, we perform trans-ethnic genome wide meta-analysis to identify shared and
distinct genetic risk factors. Third, we will perform multi-racial spatial transcriptomics and proteomics of
HS skin to elucidate cell-cell interactions, and further identify causal GWAS variants through luciferase
reporter assays. Together, these studies will advance our knowledge of the genetic architecture and
immunobiology of HS in different racial populations and identify new biologic pathways that can be
therapeutically targeted.

## Key facts

- **NIH application ID:** 10452643
- **Project number:** 5R01AR078688-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Wilson Liao
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $749,217
- **Award type:** 5
- **Project period:** 2021-07-16 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10452643

## Citation

> US National Institutes of Health, RePORTER application 10452643, Multi-racial genetic analysis of hidradenitis suppurativa (5R01AR078688-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10452643. Licensed CC0.

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