# Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository

> **NIH NIH R21** · OAKLAND UNIVERSITY · 2020 · $90,120

## Abstract

Abstract
Triggering receptor expressed in Myeloid cells (TREM) Like transcript (TLT)-1 is a prominent
platelet receptor stored in the -granules of platelets. While it is virtually absent on the surface
resting platelets, it highly expressed on the surface of activated platelets and released as a
soluble fragment (sTLT-1). TLT-1 binds to neutrophils and endothelial cells. During acute
inflammation it mediates smooth leukocyte transmigration out of the vessels protecting the
vessels from excessive bleeding. The effect is particularly prominent in the lungs. TLT-1
interaction with endothelial cells initiates cell growth and proliferation and when targeted in a
Lewis lung carcinoma model displays anti-angiogenic properties. As such our studies have
defined roles for TLT-1 in acute lung inflammation, atherosclerosis, and cancer. Here we
propose to clinically translate our findings using the rich resource presented by the NIH
biorepository. We will investigate samples from ARDS patients to find clinical correlation of
TLT-1 positive microparticles with the mortality and hospital stay. We will evaluate samples
from cardiovascular patients in the PEACE study for correlations of the soluble fragment and
TLT-1 positive microparticles with adverse cardiac events..

## Key facts

- **NIH application ID:** 10452890
- **Project number:** 7R21HL140268-03
- **Recipient organization:** OAKLAND UNIVERSITY
- **Principal Investigator:** A. Valance Washington
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $90,120
- **Award type:** 7
- **Project period:** 2021-07-17 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10452890

## Citation

> US National Institutes of Health, RePORTER application 10452890, Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository (7R21HL140268-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10452890. Licensed CC0.

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