# Mount Sinai HHEAR Network Untargeted Lab Hub

> **NIH NIH U2C** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $1,250,000

## Abstract

PROJECT SUMMARY/ABSTRACT FOR OVERALL
The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental
epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis
Resource (HHEAR) Laboratory Network Hub (formerly known as “CHEAR” in grant cycle 1). We will use a
suite of `omic' technologies to measure environmental exposures and their response across all life stages to
help NIH funded researchers determine how the environment affects human health, development and risk of
disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid
handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to
speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired
additional faculty all in preparation for this renewal application. We will leverage our substantial institutional
investments, including our new $30 million Institute for Exposomics, to serve the HHEAR Lab network and its
NIH researcher clients. Our Untargeted Resource will use molecular enviromics and metabolomics to measure
exposure to environmental chemicals and their metabolites as well as the internal response to those
exposures. We will supplement those measures with metallomics, proteomics and lipidomics. However, we are
cognizant of the ever-changing landscape of health research and have included Microbiome and Viromics to
prempt the NIH funded researchers' interest in including these measures to existing studies. We have state-of-
the-art analytical methodologies and instrumentation that were made available to CHEAR users. While we will
continue to offer these well-established methods to HHEAR clients, we are also committed to listening to the
needs of HHEAR users and develop new biomarkers to meet those needs. Our Developmental core will build
upon its highly successful work in creating novel methods to measure current and past chemical exposures in
novel biological matrices (e.g. teeth, hair, placenta, neonatal dry blood spots) and develop new assays that
arise from HHEAR's targeted and environmental resources. Our Administrative Core will coordinate planning
and communication internally among all Hub components and externally with the HHEAR Coordinating Center,
Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and
prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed,
harmonize protocols and QA/QC procedures and coordinate day-to-day operations. Our Hub will advise
applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols
and sample shipping specifications and guide them to the most innovative environmental health science.

## Key facts

- **NIH application ID:** 10453433
- **Project number:** 5U2CES030859-04
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Manish Arora
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,250,000
- **Award type:** 5
- **Project period:** 2019-09-11 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10453433

## Citation

> US National Institutes of Health, RePORTER application 10453433, Mount Sinai HHEAR Network Untargeted Lab Hub (5U2CES030859-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10453433. Licensed CC0.

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