# Molecular Mechanisms of Flow-dependent Arterial Remodeling in Peripheral Arterial Disease

> **NIH NIH R01** · EMORY UNIVERSITY · 2022 · $726,518

## Abstract

Abstract
Due to both aging and the improved longevity of patients with cardiovascular disease, the US population is at
an ever-increasing risk of developing peripheral arterial disease. Patients with peripheral arterial disease have
stiffened arteries, and peripheral arterial disease doubles patients' cardiovascular mortality. Importantly arterial
stiffening is thought to be reversible. While there are a number of factors that lead to atherosclerosis, we
propose that there are unique molecular signatures in arteries of patients with PAD that are related to the
stiffness and flow conditions of these arteries. We have identified an important role for thrombospondin-1 in
these conditions. Here we will identify and test the modifiability of these pathways using in vitro and in vivo
models of PAD conditions. In order to test translation of this work, human tissue will be used to test critical
findings. Positive results will be useful in developing targeted strategies that disrupt these pathways and
improve arterial health in our patients.

## Key facts

- **NIH application ID:** 10453472
- **Project number:** 5R01HL143348-05
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** LUKE Packard BREWSTER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $726,518
- **Award type:** 5
- **Project period:** 2018-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10453472

## Citation

> US National Institutes of Health, RePORTER application 10453472, Molecular Mechanisms of Flow-dependent Arterial Remodeling in Peripheral Arterial Disease (5R01HL143348-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10453472. Licensed CC0.

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