PROJECT SUMMARY/ABSTRACT (ADMINISTRATIVE CORE) The objective of the Administrative Core of the University of Pennsylvania Telehealth Research Center in Cancer Care (Penn TRC) is to ensure that the impact of the Center is greater than the sum of its parts. The Administrative Core will accomplish this objective by maximizing collaboration and synergy across the Research and Methods Core, Clinical Practice Network, and Pragmatic Trial. The Penn TRC’s cohesive organizing framework addresses the fundamental question of how to leverage insights from communication science and behavioral economics to design and test innovative telehealth strategies for care delivery to improve effectiveness and equity across the cancer care continuum, with an emphasis on understanding mechanisms of action. The Administrative Core will provide overarching strategic, operational, and scientific oversight to achieve this organizing framework. The specific aims of the Administrative Core are to: 1) Provide essential leadership and integration of all Penn TRC activities; 2) Create interdisciplinary research capacity and collaborations; 3) Coordinate communication and dissemination of research findings, evidence-based telehealth strategies, care delivery models, and other resources to scientific audiences and other relevant stakeholders; and 4) Monitor and evaluate Penn TRC progress and leverage findings to inform iterative refinement of Penn TRC activities and plans for future research. Completion of these aims will create a culture of exceptional interdisciplinary science and ensure success by stimulating and guiding new methodological advancements, building capacity for cancer care delivery research, and generating a robust evidence base for patient-centered, sustainable telehealth models of care at Penn and nationally. The Administrative Core leadership will ensure that the Penn TRC fulfills the National Cancer Institute’s vision to advance a national telehealth research agenda focused on improving cancer-related care and outcomes across the cancer care continuum in a rapidly changing health care, policy, technology, and communication environment.