# Clinical Translation Core

> **NIH NIH P50** · CHILDREN'S RESEARCH INSTITUTE · 2022 · $147,206

## Abstract

Project Summary
The overall goal of the Clinical Translational Core (CTC) is to efficiently and effectively move
basic and applied intellectual and developmental disability research (IDDR) findings into human
clinical studies and ultimately clinical practice. The CTC is designed to serve as a “one-stop-
shop” for IDD investigators, providing assistance and services either directly or in collaboration
with other institutional resources (especially the Clinical and Translational Science Award
(CTSA) program) at each stage of the clinical and translational research (CTR) spectrum at
CNH, GW, GU and HU. This includes deep phenotyping, recruitment, performance, analysis,
implementation, commercialization and dissemination. The proposed CTC will be coordinated
by an administrative structure that is cost effective and provides specific infrastructure supports
for DC-IDDR investigators and their teams. The direct functions of the CTC will include: 1) data
mining of large real-world evidence data sources (informatics); 2) patient recruitment and study
performance across multiple venues; 3) consultative support in biostatistics/informatics for
planning, designing, and analyzing IDDR studies; 4) connection and collaboration with other
IDDRC cores for deep phenotyping/genotyping and bio banking, and 5) training and
dissemination through a web based investigator toolkit. The specific aims are: 1) To build a
phenomics framework with a digital platform that integrates clinical and 'omics' data and a
companion biorepository; 2) To employ a multi-dimensional strategy to enhance participant
recruitment and study implementation/performance; 3) To provide IDDR-relevant study design,
biostatistical and informatics support; and 4)To develop an IDDR investigator toolkit.

## Key facts

- **NIH application ID:** 10454192
- **Project number:** 5P50HD105328-02
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** Andrea Lynne Gropman
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $147,206
- **Award type:** 5
- **Project period:** 2021-07-21 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10454192

## Citation

> US National Institutes of Health, RePORTER application 10454192, Clinical Translation Core (5P50HD105328-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10454192. Licensed CC0.

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