# Core F: Neuropathology Core

> **NIH NIH U19** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $597,787

## Abstract

Neuropathology Core Abstract
The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically
collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized
participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final
neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes,
provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all
cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will
characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel
outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data
will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will
1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics
and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and
share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem
neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.

## Key facts

- **NIH application ID:** 10454257
- **Project number:** 5U19AG068054-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Elizabeth Head
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $597,787
- **Award type:** 5
- **Project period:** 2020-09-30 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10454257

## Citation

> US National Institutes of Health, RePORTER application 10454257, Core F: Neuropathology Core (5U19AG068054-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10454257. Licensed CC0.

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