ABSTRACT The goal of this proposal “Accelerating Health Information Resource Equity for Multiracial Populations” is to harness the methods of library and information science, health disparities, and informatics research to improve access to and increase dissemination of information resources on CVD risk for Puerto Ricans, a multiracial disparity population. Puerto Ricans face unique risk factors as a result of their African, indigenous, and European ancestry; have high rates of CVD risk factors, such as smoking, hypertension, and diabetes; and experience poor treatment outcomes. We plan to: 1) synthesize and curate information resources for Puerto Ricans on CVD prevention and treatment strategies and outcomes; 2) develop information resources for improved information sharing to this population and their healthcare providers; and 3) ensure meaningful use and dissemination of these information resources through a multisector collaborative research network grounded in the principles of community-engaged research. First, we will develop multi-user health information resources tailored to Puerto Rican communities, their healthcare providers, and librarians. Second, we will adapt the Health Information Resource Equity architecture (HIRE), which leverages the existing SciCrunch®- Disco® informatics platform, a cooperative and collaborative data and resource discovery platform for scientific communities organized around diseases. The goal of the proposed HIRE architecture is to create an informatics framework for a population-centered, not disease-centered, information resource for disparity populations.