# The MobileToolbox for Monitoring Cognitive Function - Data and Statistical Analysis Core

> **NIH NIH U2C** · NORTHWESTERN UNIVERSITY · 2022 · $141,135

## Abstract

Data Core Summary
The Data and Statistical Analysis Core (Data Core) will provide both the data management and analytic
support needed to ensure the validity and reproducibility of MobileToolbox assessment tools. It will oversee
the development, refinement and maintenance of the data management infrastructure needed to ensure data
interoperability, data security and privacy (Aim 1). The data management infrastructure will include Sage
Bionetworks’ existing Synapse platform. Synapse is a cloud-based data storage and organization system
developed to facilitate sharing data, analysis and computational methods across distributed research teams.
The Data Core will also serve as a central unit to direct, manage, and coordinate both psychometric and
statistical analysis (Aim 2). The Data Core will manage and conduct the analyses needed for psychometric
validation and norming of measures included in the MobileToolbox library. The Data Core will develop new
normative values and conduct a multi-pronged validation analyses using several diverse samples. This work
will be performed by the team of statisticians and psychometricians responsible for norming and validation of
the NIH Toolbox, the Patient Reported Outcome Measurement Information System, and the International
Cognitive Ability Resource. The Data Core will calibrate newly developed item banks and validate the
MobileToolbox by conducting psychometric (item-level) and statistical (scale-level) analyses to determine
psychometric properties, structural validity, construct validity, and longitudinal validity (both “burst” and
traditional) of measures made available in the MobileToolbox Library. The Data Core will also conduct
regression-based analyses in order to create normative values for MobileToolbox Cognition measures,
including values corrected for relevant demographic variables such as age, education, race and ethnicity.
Norms for change will also be created.

## Key facts

- **NIH application ID:** 10454848
- **Project number:** 5U2CAG060426-05
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** David Michael Condon
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $141,135
- **Award type:** 5
- **Project period:** 2018-09-15 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10454848

## Citation

> US National Institutes of Health, RePORTER application 10454848, The MobileToolbox for Monitoring Cognitive Function - Data and Statistical Analysis Core (5U2CAG060426-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10454848. Licensed CC0.

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