# Cancer Center Support Grant

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $249,907

## Abstract

Kaposi’s sarcoma (KS) is a human malignancy associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). KS continue to be the most common HIV-associated cancer world-wide. KS lesions are characterized by proliferating endothelial-derived spindle cells, leaky blood vessels, and inflammatory infiltrating leukocytes. Within these lesions, inflammatory leukocytes secret cytokines and growth factors that KSHV-infected cells rely on for growth and survival. KSHVinfected endothelial cells promote the infiltration of inflammatory cells by modulating the expression of adhesion factors on its surface. We have found that KSHV infection induces the expression of novel endothelial adhesion factors and increases leukocyte adhesion and transendothelial migration. We propose to determine the mechanism by which KSHV induces leukocyte adhesion and transendothelial migration and validate the biology of this process using tissue specimens from the AIDS and Cancer Specimen Resource (ACSR). Our proposal will also identify new targets for therapies against KS in HIV-infection individuals.

## Key facts

- **NIH application ID:** 10455154
- **Project number:** 3P30CA016086-45S2
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** H. Shelton Earp
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $249,907
- **Award type:** 3
- **Project period:** 1997-06-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455154

## Citation

> US National Institutes of Health, RePORTER application 10455154, Cancer Center Support Grant (3P30CA016086-45S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10455154. Licensed CC0.

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