# Histology and Immunohistochemistry Core

> **NIH NIH P20** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2022 · $263,037

## Abstract

ABSTRACT
The Histology, Immunochemistry, and Microscopy core (HIM Core) of the COBRE provides the COBRE
investigators and other cancer researchers in Oklahoma with high quality histology, immunochemistry, and
microscopy services. This core is directed by Dr. Fung, who is a board-certified pathologist who has more than
28-years of experience in research with histologic techniques. The HIM Core has a well-equipped laboratory
that provides histologic sectioning, conventional staining, immunohistochemistry, immunofluorescence, in situ
hybridization, combined immunohistochemistry and in situ hybridization, enzyme histochemistry, and other
contemporary staining techniques. Most of these staining procedures are automated in order to maintain a high
quality. This core also provides whole slide scanning service supported by image analysis with a choice of
multiple algorithms and tissue microarray segmentation softwares. The director of the core also provides
technical advice on experimental design and methodologies appropriate for the project. The core also provides
training on the use of various microscopes including conventional bright-field, phase- and epifluorescence-
microscopy as well as new instruments for live cell imaging. This is the only such facility available in the state
of Oklahoma. Established in 2012, under the auspices of Phase I of this COBRE, the core has proven to be
critical to meet the scientific needs of the COBRE investigators in addition to catering the needs of other
cancer researchers in Oklahoma. During Phase I of this COBRE, 6 COBRE Promising-Junior or target
investigators and 64 non-COBRE investigators used this core. The mission of the HIM Core is accomplished
under the following three specific aims: 1. Consultation on experimental design and interpretation of results; 2.
Histological methods and staining services; and 3. Whole slide scanning, image analysis, and live cell imaging
services.

## Key facts

- **NIH application ID:** 10455518
- **Project number:** 5P20GM103639-10
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Kar-Ming Fung
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $263,037
- **Award type:** 5
- **Project period:** 2012-09-05 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455518

## Citation

> US National Institutes of Health, RePORTER application 10455518, Histology and Immunohistochemistry Core (5P20GM103639-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10455518. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*