# NEUROGENOMICS CORE

> **NIH NIH P50** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $85,462

## Abstract

PROJECT SUMMARY/ABSTRACT – NEUROGENOMICS CORE 
Neurogenomics research, including analysis of DNA, RNA and the epigenome, consisting of investigation of 
chromatin and methylation, is increasingly important in studies of intellectual and developmental disabilities 
(IDDs). For example, neurogenomics analysis can identify the cause of human IDDs as well as determine the 
mechanism by which genes are regulated in animal or cell-based models. The Neurogenomics (NGEN) Core 
provides standard and innovative genomic assays that range from genotyping of DNA variants in human 
subjects through single cell RNA-sequencing or evaluation of accessible chromatin in neural progenitor cells. 
The NCEI with the NGEN Core will establish spatial transcriptomic technology, making it possible to investigate 
gene expression in the context of tissue architecture. Further, the NGEN Core provides computational and 
bioinformatic analysis of large datasets that emerge from next-generation sequencing (NGS) experiments and 
will train students and postdoctoral fellows. The NGEN core is flexible to relinquish old services that are no 
longer utilized or cost effective, to implement innovative services that will enhance IDD research and discovery. 
The team consists of a Director and Associate Director with complementary expertise in human genetics, 
functional genomics and epigenomics. The Operations Directors have hands-on roles in implementing and 
establishing new technologies or bioinformatic services that are performed by senior technical staff. The 
NGEN Core has an advisory committee needed to ensure optimal service and to help decide which services to 
offer in the Core. The NGEN Core Components are part of established shared facilities at Einstein that also 
has oversite from the Cancer Center and College. One of the challenges in performing genomics research is 
how to choose among many different assays that are available. The NGEN Core provides guidance to IDDRC 
investigators in a prioritized manner, from study design, to experimental optimization to bioinformatic analysis. 
For this, the Directors meet with individual investigators to provide guidance in helping to choose assays that 
are best suited for their particular research question. Members of the IDDRC will receive prioritized access to 
NGEN Core services and personalized consultation. The IDDRC Pilot Award and Voucher program is also 
available through the ADM Core on a competitive basis, making it possible for investigators to initiate 
neurogenomics projects even if current grant funding is limited. Through this facilitated availability of a wide 
range of services and innovative technologies involving critical aspects of genomic analysis, the NGEN core is 
an essential component of the IDDRC.

## Key facts

- **NIH application ID:** 10455677
- **Project number:** 5P50HD105352-02
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** BERNICE E MORROW
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $85,462
- **Award type:** 5
- **Project period:** 2021-07-23 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455677

## Citation

> US National Institutes of Health, RePORTER application 10455677, NEUROGENOMICS CORE (5P50HD105352-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10455677. Licensed CC0.

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