# UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)

> **NIH NIH U54** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $768,872

## Abstract

ABSTRACT (OVERALL)
The overarching goal of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work in
partnership with the PKD Consortium, under the direction of the U24 Central Coordinating Site (U24-CCS) and
NIDDK, to eliminate obstacles in cystic kidney disease related research that are hindering progress toward
the development of improved and innovative treatment strategies for cystic kidney disorders. To accomplish this
goal, the UAB-CCKDCC has assembled a multidisciplinary team of researchers and clinicians who will
direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The
collective mission of these Cores is to support, accelerate, and expand basic and translational research activities
being performed by PKD Consortium members. The Center will focus on the development of resources to
analyze cilio-cystic disease protein function, localization, and interactions and how defects in these functions
contribute to the pathogenic mechanisms involved in cyst initiation and progression. The Center will complete its
mission through providing ready access to clinical data and biomaterial from CCKD patients, through
the development and distribution of patient-relevant cell and animal models of CCKD, and through the
development of methodology to utilize these models to ascertain the efficacy of candidate therapies to slow
disease progression using a standardized, cost-effective, and longitudinal imaging and analysis strategies. The
services and resources being made available by the Center along with the integration between each of the
Cores will expand research activities well beyond that capable in most individual laboratories and will accelerate
the pace of research into causes and possible cures of cystic kidney diseases by providing for high quality,
robust, and reproducible outcomes needed to prioritize drugs for future clinical trials.

## Key facts

- **NIH application ID:** 10455717
- **Project number:** 5U54DK126087-03
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Bradley K. Yoder
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $768,872
- **Award type:** 5
- **Project period:** 2020-07-20 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455717

## Citation

> US National Institutes of Health, RePORTER application 10455717, UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) (5U54DK126087-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10455717. Licensed CC0.

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