# Core B: Reagent/Service Core

> **NIH NIH P01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $248,830

## Abstract

Core B Summary 
The three research projects that comprise this Program Project are all focused on understanding molecular 
and cellular events and mechanisms leading to bladder tumorigenesis of both major bladder cancer (BC) 
variants and molecular subtypes. In addition to the intellectual and experimental synergies that link the 
individual projects into a cohesive program, each of the three proposed research plans all depend upon a 
common set of critical reagents and services made available on a continuous basis for their success. These 
include but are not limited to a set of cultured cell lines that represent different grades and stages of major BC 
variants and molecular subtypes, unique mouse models of bladder cancer developed/used by project leaders 
Dr. Wu, Dr. Tang and Dr. Huang, nucleic acid reagents, antibodies and cDNA constructs. Obviously, it would 
not make sense, nor would it be an efficient use of time, money, and resources for each laboratory to 
independently generate, procure, characterize, and maintain all these reagents. Instead, we have established 
a centralized Reagent and Service Core, one of whose purposes is to serve as a central repository for key 
reagents and provide a central supply for these important research tools that can be shared by all involved in 
this Program Project. In addition to the cost-effectiveness, this approach offers the advantage of ensuring the 
quality of these shared reagents across the individual projects. Providing supplies of cell lines, mouse tissues 
and animal models from a centralized core eliminates variability in reagent handling, facilitating data 
comparison amongst the three individual projects. Furthermore, it promotes additional interactions among the 
project directors and guards against accidental loss of invaluable reagents in emergency situations such as 
power outages (which we last experienced in 2012 during Sandy Superstorm). Finally, the Core B will also 
provide pathology and statistical support for the individual projects. The specific aims of the Core are: i) To 
maintain a centralized supply and distribute a common core set of reagents vital to support the research efforts 
of individual component projects; ii) To collect mouse specimens and provide the necessary pathology support 
service; and iii) To provide dedicated statistical support. Success of this Core will be an essential factor for the 
studies that have been proposed in this program project.

## Key facts

- **NIH application ID:** 10455733
- **Project number:** 5P01CA165980-09
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Eric Moon-shong M. TANG
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $248,830
- **Award type:** 5
- **Project period:** 2013-09-12 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455733

## Citation

> US National Institutes of Health, RePORTER application 10455733, Core B: Reagent/Service Core (5P01CA165980-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10455733. Licensed CC0.

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