# Resident Memory T Cells

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 2022 · $604,558

## Abstract

Project Summary
The goal of this proposal is to make significant advancements in our understanding of resident memory T cell
(TRM) biology that will inform mechanisms of immunity and vaccination. TRM longevity and stability will be
rigorously examined. Moreover, the proposal will test the hypothesis that TRM exhibit developmental plasticity
and retrograde migration, giving rise to cells contained within circulating T cell populations that are significantly
advantaged to reconstitute TRM-based immunity specifically at their previous site of residence. Lastly, the
ontogeny and function of lymph node TRM will be defined.

## Key facts

- **NIH application ID:** 10455752
- **Project number:** 5R01AI146032-03
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** DAVID MASOPUST
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $604,558
- **Award type:** 5
- **Project period:** 2020-08-19 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10455752

## Citation

> US National Institutes of Health, RePORTER application 10455752, Resident Memory T Cells (5R01AI146032-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10455752. Licensed CC0.

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