# Core B: Integrative Genomics Core

> **NIH NIH U19** · BRIGHAM AND WOMEN'S HOSPITAL · 2022 · $245,039

## Abstract

Core B: Integrative Genomics Core
ABSTRACT
This U19 re-competing proposal entitled “Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated
Respiratory Disease” seeks to understand the mechanisms of chronic rhinosinusitis with nasal polyposis
(CRSwNP) and aspirin exacerbated respiratory disease (AERD) at a multi-omic molecular and cellular level. The
Integrative Genomics Core (IGC) will utilize cutting-edge technologies and computational methods, many of
which were developed by our group, to support the objectives of the three Projects, each of which is focused
on a different aspect of Type II immunopathology (T2I). The IGC will be based at the Raychaudhuri lab at the
Brigham and Women’s Hospital (BWH), where the BWH Single Cell Genomics Core is also based. The IGC is
composed of researchers with 10+ years of experience leading large-scale functional genomics projects,
processing large datasets, and performing statistical analyses to integrate different layers of multi-dimensional
information for the understanding of immune-mediated diseases. The IGC has a robust informatics infrastructure
where terabytes of data can be stored and high-performance computing jobs can be run. Specifically, the IGC
will (i) generate the single-cell and bulk datasets profiling RNA, open chromatin and protein levels for all three
Projects, (ii) process and perform the quality check of each dataset, (iii) apply normalization and batch correction
procedures, (iv) perform reproducible bioinformatic and statistical analyses, and (v) archive all experimental data
and results on a firewall and password protected internal network. The IGC will perform analyses according to
each Project’s needs to gain insights into mast cell heterogeneity and differentiation (Project 1), basal cell
differentiation and senescence programs (Project 2), and the molecular underpinnings of drug response in a
clinical trial (Project 3). Additionally, the IGC will facilitate synergy and data integration across all three Projects,
contributing to new mechanistic insights into the control and therapy of T2I in CRSwNP and AERD.

## Key facts

- **NIH application ID:** 10456242
- **Project number:** 5U19AI095219-12
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Soumya Raychaudhuri
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $245,039
- **Award type:** 5
- **Project period:** 2011-07-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10456242

## Citation

> US National Institutes of Health, RePORTER application 10456242, Core B: Integrative Genomics Core (5U19AI095219-12). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10456242. Licensed CC0.

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