# Clinical and Translational Core

> **NIH NIH U54** · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $189,955

## Abstract

Project Summary
Despite recent advances in the development and testing of novel therapies for Autosomal Polycystic Kidney
Disease (ADPKD), additional translational and clinical investigations are needed to better elucidate the
mechanisms of disease progression and identify promising new therapies. The overall goals of the Maryland
PKD Research and Translation Center Clinical and Translational Core are to create a robust platform to
support clinical and translational investigation of human ADPKD, through the comprehensive phenotyping of
ADPKD patients linked to a complete biorepository including human tissue samples and cell cultures, and
prospectively ascertained PKD-related outcomes. We propose to develop:
 1) A prospective observational study of N=200 ADPKD patients with comprehensive phenotyping, linked
to a robust specimen biorepository, along with targeted plasma- and urine-based biomarker
measurement and deep genotyping with whole exome sequencing.
2) A human ADPKD human tissue bank in collaboration with our Cell Culture and Engineering Core,
 comprising nephrectomy specimens with cyst-specific tissue samples, cyst fluid, and primary and
 immortalized cell cultures, linked to clinical phenotyping.
3) An electronic ADPKD patient registry, to promote the rapid and efficient screening and recruitment of
 APKD patients for clinical trials and ancillary observational studies.
These resources will be promoted to and shared with new and established investigators in collaboration
with the Administrative Core and the PKD Central Coordinating Site (CCS). We will further collaborate with
investigators in the discovery and validation of novel biomarkers of ADPKD severity and progression, using
our robust biorepository and biomarker laboratory facilities.

## Key facts

- **NIH application ID:** 10456643
- **Project number:** 5U54DK126114-03
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Stephen L. Seliger
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $189,955
- **Award type:** 5
- **Project period:** 2020-08-24 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10456643

## Citation

> US National Institutes of Health, RePORTER application 10456643, Clinical and Translational Core (5U54DK126114-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10456643. Licensed CC0.

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