# Randomized Trial of Inpatient Palliative Care for Patients with Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $438,365

## Abstract

PROJECT SUMMARY/ABSTRACT
Overview: The goal of this study is to demonstrate the efficacy of inpatient palliative care integrated with trans-
plant care for improving quality of life (QOL) and mood of patients with hematological malignancies undergoing
hematopoietic stem cell transplantation (HCT) and their caregivers.
Background: Patients undergoing HCT endure an immense physical and psychological symptom burden during
their 3-4 week transplant hospitalization with 50-70% reporting moderate to severe nausea, fatigue, diarrhea,
and pain, and over 40% reporting significant depression and anxiety symptoms. Importantly, patients' QOL de-
terioration during HCT predicts their QOL and psychological distress post-HCT. Caregivers (i.e. family and
friends) of patients undergoing HCT also struggle emotionally during and after their loved one's transplant. De-
spite the burden experienced by these individuals, interventions are lacking to improve their QOL and care. We
completed a single center randomized trial of inpatient integrated palliative and transplant care in patients un-
dergoing HCT and demonstrated clinically significant improvements in patients' QOL, symptom burden, depres-
sion, and anxiety during HCT. Notably, the effects of the intervention were sustained three and six months post-
HCT with improvement in patients' depression and post-traumatic stress symptoms. Caregivers of patients ran-
domized to the intervention reported improvements in their coping and depression. Thus, this is the first trial to
establish both the feasibility and preliminary efficacy of inpatient integrated palliative and transplant care in im-
proving outcomes of patients with hematologic malignancies and their caregivers.
Research Plan: We propose to conduct a multi-site randomized trial of inpatient integrated palliative and trans-
plant care versus transplant care alone in patients with hematologic malignancies undergoing HCT. The primary
goal of this study is to demonstrate definitively the efficacy of inpatient palliative care for improving patient and
caregiver reported outcomes in a multi-site trial with a large and more diverse patient population. We will also
assess the impact of the palliative care intervention on participant-reported QOL and psychological outcomes
post-HCT. Lastly, we will explore potential mediators and moderators of the inpatient integrated palliative and
transplant care model on patient-reported QOL.
Environment: This project will be conducted at Massachusetts General Hospital, Fred Hutchinson Cancer Re-
search Center, and the University of Miami. These sites have the palliative care and transplant experience,
infrastructure, and processes to conduct this trial. The MGH research team has the expertise in developing and
testing integrated palliative care models for patients with solid tumors and hematologic malignancies to ensure
the successful implementation and evaluation of the palliative care intervention across study sites.
Relevance...

## Key facts

- **NIH application ID:** 10456762
- **Project number:** 5R01CA222014-05
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Areej El-Jawahri
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $438,365
- **Award type:** 5
- **Project period:** 2018-08-09 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10456762

## Citation

> US National Institutes of Health, RePORTER application 10456762, Randomized Trial of Inpatient Palliative Care for Patients with Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation (5R01CA222014-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10456762. Licensed CC0.

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