# The MRN complex in Lymphocyte Development and Genome Stability

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $658,002

## Abstract

Abstract
Cellular responses to DNA double strand breaks require rapid communication between specialized
DNA damage recognition complexes and the core cell cycle machinery, but this important relationship
is poorly understood. Mre11, a core component of the DNA damage recognition machinery that is
mutated in ataxia-telangiectasia like disorders (ATLD), has been shown to interact with cyclin
dependent kinase 2 (CDK2), a core component of the cell cycle machinery.
In this proposal we will test the overarching hypothesis that Mre11 interacts with and controls CDK2
to provide a rapid switch between the normal cell cycle and the DNA damage response. We will
determine roles that Mre11-CDK2 interaction plays in diverse biological contexts such as specialized
DNA recombination in lymphocyte development, and S phase checkpoint responses more generally.
The studies proposed herein take advantage of previously constructed murine systems, along with
new mouse lines that model human ataxia telangiectasia-like disorder. Collectively, the proposed
studies will significantly contribute to our understanding of cellular responses to DNA damage and
their associated diseases.

## Key facts

- **NIH application ID:** 10456876
- **Project number:** 5R01HL153068-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DAVID O FERGUSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $658,002
- **Award type:** 5
- **Project period:** 2021-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10456876

## Citation

> US National Institutes of Health, RePORTER application 10456876, The MRN complex in Lymphocyte Development and Genome Stability (5R01HL153068-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10456876. Licensed CC0.

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