# Core F:  Systems Biology & Biostatistics

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $284,373

## Abstract

PROJECT SUMMARY/ABSTRACT –SYSTEMS BIOLOGY & BIOSTATISTICS CORE F
The RUSTBELT CFAR Systems Biology & Biostatistics Core F provides support to a wide range of CFAR
investigators by offering new multi-omic technologies, advanced biostatistics and computational analysis of “big
data,” a stronger foundation in functional immunology studies, and a comprehensive ‘omic data management
and training platform. The key mission of Core F is to provide systems biology approaches that allow for
integration of different layers of host immune responses, from molecular triggers of immune responses to
transcriptional signatures and interaction with resident microbiota. We will continue to support functional
immunology studies that remain fundamental to HIV research. The Core assists investigators with research rigor
and reproducibility through implementation of best practices for study design, analysis, and public sharing of
results. In Aim 1 Core F will support genomics and microbiome research in HIV immunology and pathogenesis
by providing users with a robust technological platform for transcriptional analysis by RNA-seq as well as deep
sequencing in clinical and animal models of HIV infection. In Aim 2 Core F provides training and consultation in
functional immunology as well as centralized access to state-of-the-art immunologic technologies, protocols, and
training for the isolation, manipulation, culturing, and expansion of primary immune cells from blood and tissue,
thereby supporting the RUSTBELT CFAR’s HIV transmission, gender research, cure, and pathogenesis
translation objectives. In Aim 3 Core F facilitates all aspects of systems biology studies, by offering a centralized
data acquisition, management, and reporting structure for all cohorts and ‘omics, using high-capacity assay and
analysis workflows as well as publicly available ‘omic data to build publications and databases. Lastly, in Aim 4
This service function includes the collection and preparation of ‘omic and functional data for coordination and
distribution to investigators, collecting associated de-identified patient annotations needed for analysis, and study
publication. Core F Core F performs biostatistical correlate analysis to identify key drivers of protective immune
responses, assist in designing validation strategies and writing manuscripts, and provide the metadata and data
standardization pipelines for upload of results to public databases. By providing fundamental immune modeling
support paired with multi-omic methodologies to identify key drivers or biomarkers of the host-virus interface in
HIV, Core F will foster the complete systems biology approach necessary to support CFAR investigators in their
translational research toward HIV cure, prevention, gender discrepancies, response to treatment, and the
immunopathological landscape.

## Key facts

- **NIH application ID:** 10457727
- **Project number:** 2P30AI036219-26A1
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Mark James Cameron
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $284,373
- **Award type:** 2
- **Project period:** 1997-04-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10457727

## Citation

> US National Institutes of Health, RePORTER application 10457727, Core F:  Systems Biology & Biostatistics (2P30AI036219-26A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10457727. Licensed CC0.

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