PROJECT SUMMARY/ABSTRACT Core E The Core will provide severe asthma investigators from each of the three Projects all facets of statistical support, including experimental design, analysis, and interpretation. Core personnel will interact with PPG investigators in all stages of research, including the formulation of research questions and hypotheses, experimental design, data management, data analysis, result interpretation, preparation of scientific manuscripts and grants, dissemination of results, and the assessment of stepwise success and barriers to meeting overall project objectives. Specific aims are: (1) to collaborate with project investigators to ensure that all clinical and translational studies and experiments are properly designed, and (2) to provide support to project investigators in the statistical analysis and reporting of data from experiments and clinical studies. These aims will be accomplished by a team consisting of Yi Zhao, PhD (core director) and James Slaven, MS providing biostatistical support and expertise. There is no comparable core for pulmonary data analysis at IU, though there are complementary programs for Computational Biology and Bioinformatics.