# Personalized Perioperative Medicine: Translational Studies in the Prevention of Postoperative Pain and Opioid Misuse

> **NIH NIH R35** · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $137,764

## Abstract

PROJECT SUMMARY
 Surgery is an increasingly common event, impacting over 230 million people annually. Post-surgical
pain is variable in severity and duration, but a significant minority (20-30%) of patients experience surgical site
pain lasting a year or longer. Such persistent postsurgical pain causes physical and mental suffering and
disability, and long exposure to postoperative opioids also puts patients at risk of misuse and addiction.
Despite excellent preclinical research into the molecular events involved in the transition of acute to chronic
pain after injury, little success at translating these findings to actual prevention of persistent postoperative pain
in human patients has been realized. My research program has focused on building a working human model of
this transition, by systematic and longitudinal study of pain before, during and after a variety of surgeries.
Importantly, we have focused our efforts to identify risk factors to predict those who will actually develop
chronic postsurgical pain, rather than those who won’t (70-80%), to make study of this problem more efficient.
 A crucially important factor in determining the trajectory of post-surgical pain appears to be the capacity
for amplification in the circuitry of the pain system, whereby incoming painful input may be increased to the
point of intense discomfort. This amplification may be protective in the short term, but dysfunctional if it is
excessive or persistent. In our psychophysics lab, we study measures that indicate an excessive (temporal
summation of pain, TSP) or prolonged response (painful after sensations, PAS) amplification response of the
nervous system in response to standardized pain stimuli. Amplification can also occur at a psychosocial level,
where stress, sleep disruption, and catastrophizing (a mental process by which rumination, magnification, and
worry increase salience and importance) increase pain perception. Importantly. TSP, PAS, stress, sleep
disturbance and catastrophizing are much more prominent in some individuals, and account for a sizeable
amount of the variation in postsurgical pain severity (and far more than the surgical extent). We have adapted
these tests to easily and non-invasively test this “amplification phenotype” in individuals BEFORE they have
surgery, using modified bedside quantitative sensory tests (QSTs), and brief, validated questionnaires.
 We propose to use these measures of preoperative amplification phenotype, in order to help target
both known and novel non-opioid preventive treatments to those individuals who need them most. This is my
area of expertise, as I am an anesthesiologist with formal training in pain neuroscience, psychophysical and
psychosocial assessment, and practical experience in conducting translational studies in post-surgical pain.
Broadly, my research plan will use this human translational pain model: 1) to speed testing of pain preventive
therapies, 2) to develop strategies to reduce pain and op...

## Key facts

- **NIH application ID:** 10458294
- **Project number:** 3R35GM128691-04S1
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** KRISTIN SCHREIBER
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $137,764
- **Award type:** 3
- **Project period:** 2018-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10458294

## Citation

> US National Institutes of Health, RePORTER application 10458294, Personalized Perioperative Medicine: Translational Studies in the Prevention of Postoperative Pain and Opioid Misuse (3R35GM128691-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10458294. Licensed CC0.

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