# SWG 1 -Translational Research on Substance Use SWG

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $51,923

## Abstract

SWG TRSU: Project Summary/Abstract: The Translational Research on Substance Use (TRSU) Strategic
Working Group (SWG) will connect expertise in community engagement with behavioral, basic and clinical
scientists across the CFAR cores and broadly across the UCLA and CDU campuses. The TRSU will generate
novel and high impact research at the intersection of HIV prevention, treatment and ART-free remission, and
substance use/misuse (SU) by examining best practices from the perspective of participants in CFAR activities
on how SU data is generated and used. The TRSU moves the field beyond existing approaches for measuring
and intervening on substance use/misuse to examine acceptability and implementation challenges at the
community level when studying rigorous characterization of SU exposure that can be used to examine impacts
on the immune system, and the HIV reservoir. This TRSU will accelerate science in OAR priority areas by
emphasizing that cultural relevance and community competency must be assessed for laboratory and behavioral
assessments of drug products and SU exposure in individuals relevant to SU and misuse in the context of HIV
infection. This will enable scientists working to understand the dynamics of the HIV reservoir in vivo to have
better measures of SU, people working on improving rates of viral suppression will be able to obtain validated
measures of SU exposure that are acceptable to the community, and those working on HIV prevention will be
better able to identify those who can benefit from interventions to address SU disorders with identification of drug
products in use. It also will examine how to feedback the findings on drug products and levels of use in local
communities from laboratories and scientists in the CFAR to study participants and local care providers. These
goals will be achieved by: identifying innovative methods for assessment of SU that can be used in studies of
the HIV reservoir and immune reconstitution as well as in epidemiological, basic, and clinical science research
to stop HIV. The TRSU will increase access to and stimulate support for multidisciplinary integrated assessments
of SU and misuse such as hair sampling, drug product testing by strips/and or mass spectrometry in community
settings, and ecological momentary assessments by bringing new investigators from outside HIV into this work.
The TRSU will assess community acceptability of methods of assessment of SU most relevant to research on
HIV prevention, treatment, and ART-free remission; and enhancing the dissemination of laboratory and clinical
assessments of SU among research participants with the development of best practices for community
engagement. The TRSU will enhance cultural relevance by engaging community participation in guiding
development and use of research tools that can potentially advance intersectional studies of substance
use/misuse and the three CFAR themes of HIV Prevention, Treatment and ART-Free Remission.

## Key facts

- **NIH application ID:** 10458376
- **Project number:** 1P30AI152501-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Pamina Mae Gorbach
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $51,923
- **Award type:** 1
- **Project period:** 2022-04-08 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10458376

## Citation

> US National Institutes of Health, RePORTER application 10458376, SWG 1 -Translational Research on Substance Use SWG (1P30AI152501-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10458376. Licensed CC0.

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