# Immunopathology Core

> **NIH NIH P20** · OKLAHOMA STATE UNIVERSITY STILLWATER · 2022 · $176,963

## Abstract

PROJECT SUMMARY 
The specific aim of the Immunopathology Core Program (IPC) is to provide pathology 
and immunology support to COBRE and other Oklahoma Center for Respiratory and 
Infectious Diseases (OCRID) investigators. Services provided by the IPC include a broad 
range of pathology support including gross necropsy and tissue collection, tissue 
processing, sectioning of either frozen or paraffin-embedded tissues, routine and special 
stains, immunohistochemistry (IHC), immunofluorescence (IFC), and coordination of 
ancillary services (clinical pathology, bacteriology, virology, toxicology). Immune 
responses important in the development of disease are characterized by evaluation of cell- 
mediated immunity (ELISPOT, flow cytometry for intracellular IFNγ) and phenotypic 
identification of inflammatory cells within lesions (IFC, IHC, flow cytometry). The IPC 
will also coordinate with the Animal Models Core (AMC) and Molecular Biology Core 
(MBC) to assist investigators with humoral immunity (serology, ELISA) and quantitation 
of cytokine gene expression (real-time PCR) respectively. To achieve this aim, the IPC is 
staffed by three board-certified pathologists with experience in animal models and 
respiratory/infectious disease research and an experienced, extensively cross-trained 
technician. The IPC has the resources in place to serve as the foundation and a strong 
institutional commitment to ensure development of the IPC into a self-sustaining facility 
integral to the research infrastructure of OCRID.

## Key facts

- **NIH application ID:** 10459261
- **Project number:** 5P20GM103648-10
- **Recipient organization:** OKLAHOMA STATE UNIVERSITY STILLWATER
- **Principal Investigator:** Rudragouda Channappanavar
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $176,963
- **Award type:** 5
- **Project period:** 2013-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10459261

## Citation

> US National Institutes of Health, RePORTER application 10459261, Immunopathology Core (5P20GM103648-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10459261. Licensed CC0.

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