# Scale it up: Effectiveness-implementation research to enhance HIV-related self-management among youth

> **NIH NIH U19** · FLORIDA STATE UNIVERSITY · 2021 · $1,147,426

## Abstract

Abstract
 Despite the substantial declines in HIV transmission and increases in lifespan among those living with
HIV achieved over the past decade, full benefits that should be possible based on the tools and interventions
currently available have yet to be realized in youth, in large part because efficacious interventions for this age
group have not been brought to scale. To be effective, youth must be fully engaged in interventions at every
stage of the HIV care (treatment and prevention) cascades: HIV testing, linkage to care, timely initiation of
care, persistence and adherence to antiretroviral care. At-risk HIV-negative youth need to be consistently
engaged in prevention strategies such as PEP and/or PrEP as indicated, consistent safer sex practices and
repeat HIV testing. Our U19 project - Scale It Up - specifically focuses on the process of improving self-
management among youth including: 1) the identification of interventions that are efficacious and effective for
improving self-management in YLH and at risk youth; 2) the multi-site implementation of an intervention shown
to be efficacious in improving self-management; and 3) the assessment of the Five Components of Self-
Management Model and how these vary over time, are directly improved by interventions, and mediate
intervention effects. Our team has also been at the leading edge of implementation Science research related to
HIV prevention and care. We are actively committed to aggressively moving beyond simple efficacy and
effectiveness RCTs. The four Research Projects proposed in Scale It Up, all addressing self-management, will
continue to develop the field of Implementation Science by employing three types of effectiveness-
implementation hybrid designs. The studies further synergize by utilizing Aaron’s Exploration, Preparation,
Implementation, Sustainment (EPIS) model to guide the proposed Implementation Science efforts. Our
proposed Implementation Science Core, coupled with the cost effectiveness expertise of our Analytic Core, will
be focused on the central notion of “Scale It Up” – taking efficacious self-management interventions and
expeditiously moving them into practice while sustaining effectiveness. Scale It Up has assembled research
teams who will develop, test, and bring to practice self-management interventions that positively impact the
youth HIV prevention and care cascades. We will achieve these goals by: 1) Designing, conducting and
evaluating self-management interventions grounded in the 5-component Self-Management Model and
expeditiously moving effective programs into practice; 2) Developing, deploying and disseminating new
methods for implementation and implementation analysis with a strong theoretical foundation; and 3) Engaging
with the other funded U19s to identify additional opportunities to advance the implementation science and self-
management science.
Project Summary/Abstract Page 200

## Key facts

- **NIH application ID:** 10459959
- **Project number:** 3U19HD089875-06S1
- **Recipient organization:** FLORIDA STATE UNIVERSITY
- **Principal Investigator:** SYLVIE NAAR
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,147,426
- **Award type:** 3
- **Project period:** 2016-09-30 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10459959

## Citation

> US National Institutes of Health, RePORTER application 10459959, Scale it up: Effectiveness-implementation research to enhance HIV-related self-management among youth (3U19HD089875-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10459959. Licensed CC0.

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