# Case Western Reserve University StrokeNet Regional Coordinating Center

> **NIH NIH U24** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $305,730

## Abstract

Cleveland is an urban community with several healthcare systems, internationally renowned researchers
and a rich history of cooperation with respect to stroke care. University Hospitals of Cleveland (University
Hospitals), The Cleveland Clinic, MetroHealth and the Louis Stokes Cleveland VA Medical Center
(Cleveland VA) are affliated with Case Western Reserve University (CWRU) and collaborate in a Clinical
Translational Science Collaborative (CTSC- funded by a CTSA) to enhance training, research, and
discovery in Cleveland. In 2013 we were awarded a Regional Coordinating Center (RCC) as part of NIH
StrokeNet. This application is to to renew that grant. We have expanded our RCC adding sites in Toledo
(Mercy St Vincent Medical Center or Mercy St Vincent), Columbus (OhioHealth), Grand Rapids, Michigan
(SpectrumHealth) and Morgantown, WV (West Virginial University (WVU). The inclusion of one county
hospital with a large emergency department, VA hospital, and two urban academic medical centers, one
academic medical center in a rural state ensures a diverse patient and study population.
Our RCC has excellent participation and quality metrics on StrokeNet studies, including the highest
enrollment in StrokeNet study in the Great Lakes Region. We have a diverse research community, with
clinical researchers, basic scientists, engineers and biotech companies, to collaborate with and bring new
projects to the network. We have large hospitals systems, including 3 hospitals ranked in the top 50
Neurology and Neurosurgery programs in the country, 6 Comprehensive Stroke Centers and a seventh site
that will be reviewed for Comprehensive designation in October 2017. We have state of the art
transportation resources including critical care air transport with physicians and nurse practicioners on board
and 2 hospital systems with mobile stroke units that administer thrombolytics in the field or en route to the
hospital. We have special expertise in penumbral imaging, acute endovascular therapy and rehabilitation
and functional electrical stimulation. We propose a multi-teired leadership. Dr Sophia Sundararajan and Dr.
Ken Uchino will lead the RCC as PIs, and representatives from each of the eight hospitals will serve on the
Executive committee with the PIs, as will a Project Manager and Training Director. The Executive
Committee includes senior and more junior investigators and will oversee and run all aspects of the RCC,
but also provide mentorship for more junior investigators. Our leadership succession plan has already
successfully mentored Drs Sundararajan and Uchino who will assume the Co-PI roles of this application.
With the expertise and resources detailed in this application, the Case Western Reserve University RCC will
be well positioned to enhance the structure and organization of our RCC and further accelerate participation
in clinical trials for stroke acute intervention, prevention and rehabilitation in both adults and children.

## Key facts

- **NIH application ID:** 10460337
- **Project number:** 5U24NS107270-05
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** SOPHIA SUNDARARAJAN
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $305,730
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-12-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10460337

## Citation

> US National Institutes of Health, RePORTER application 10460337, Case Western Reserve University StrokeNet Regional Coordinating Center (5U24NS107270-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10460337. Licensed CC0.

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